ISSN: 1582-5388





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††† Publichealth


Project management Ėa way of reducing uncertainties

Elena Lungu

Abstract. Projects and project management operate in an environment broader than that of the project it self. A project is often regarded as a desired goal, which can be realized with the available means. In this sense we try to increase our chances and minimize the risks. This article comprises concepts, principles, models of project management and different stages of a project.

Key words: project, project management, product-market combinations, concepts, principles, models FULL TEXT.PDF


Trend of methemoglobinemia cases in eastern Romania

Marieta Vasilov, St.Condrea, Anca Cristea, A.Chiroşcă, Antoneta Dobreanu, Aurora Georgescu, Elena Şerban, Elena Vrabie

Abstract. The results of an epidemiological descriptive study based on the cases reported by the Districtual Public Health Departments are presented. The incidence of methemoglobinemia rates in 0-1 years aged infants varied between 1.5 o/oo and 7.0 o/oo during 1996-2000 in eastern Romania territory. An increasing trend of cases was also found and the results outlined that the highest frequencies appeared in the infantís early life (three months). The analyses of well water samples indicated both chemical (especially by nitrogenous substances) and bacteriological contamination, the frequencies ofimproper samples varying between 45.8% and 65.9 %. Thus, the high risk areas in Moldova territory were defined and scaled on risk level.

Key words: infants, methomoglobinemia cases, nitrites, nitrates in water, descriptive epidemiology FULL TEXT.PDF


A follow-back of men and women who grew up in Romanian orphanages

N. Lie, D. Murăraşu

Abstract. Abandonment and institutionalization were studied retrospectively in 55 men and 20 women who had grow up in orphanages. The major causes of abandonment was being born by a single/unmarried mother or by poor parents. Family adversity and parental dysfunction was the major cause of only one fourth of the abandonments. More than half of abandoned children were admitted during the first six months of life, and only one quarter after age three. The average time spent in orphanages was 14 years for boys and 17 years for girls. No more than 25% of the boys and 12% of the girls were keeping in contact with the family during in-care. As many as 73% of the boys and 41% of the girls were physically abused and 23% of the girls and 17% of the boys were sexually abused in the orphanage.

Key words: abandonment of children, institutionalized children, physical abuse, sexual abuse, orphanages, dystrophics FULL TEXT.PDF


Parental dermatoglyphic aspects in trisomy 21

Ana Ţarcă

Abstract. The paper deals with an analysis of digito-palmar dermatoglyphics with the parents of 54 children with Trisomy 21 (Down Syndrome) studied before [15]. The results obtained confirm the data found in the foreign specialised literature according to which many of the dermatoglyphic malformations present at children with Trisomy 21 can also be found to their apparently healthy parents but in a smaller number, because here they signal only the presence of the Trisomy 21 (partial Trisomy 21, Trisomy 21 by balanced translocation or mosaic Trisomy 21) while in the case of the affected children these abnormalities are also the graphic expression of the multiple malformations that accompany their total or unbalanced translocation Trisomy 21. Consequently, the author considers that the dermatoglyphic distortions illustrated in both cases (parents and their children), could be used as pathological indicators in the identifying of the carrier persons of the inapparent phenotypically Trisomy 21 but having the risk of giving birth to children with complete Trisomy 21 and specific multiple malformations.

Key words: Dermatoglyphics, Trisomy 21 (Down Syndrome), distortions (anomalies) FULL TEXT.PDF


Antioxidant enzyme levels in reactive arthritis and rheumatoid polyarthritis

Irina Popovici, Elena Rezuş, Gabriela Mancaş

Abstract. This study is based on the comparative analysis of 38 patients with reactive arthritis defined by Amor criteria, a group of 33 patients with rheumatoid polyarthritis and 50 healthy controls. Antioxidant systems (glutathione peroxidase, superoxide dismutase, catalase)were investigated in inflammation consecutive to immune and infectious syndromes. Our study showed that reactive arthritis and rheumatoid arthritis is associated with enhanced oxidative stress. The lower levels of natural blood antioxidant enzyme, were related to severe forms of disease. The investigation of oxidative metabolism lies at the basis of antioxidant therapy that could influence the natural course of reactive arthritis and polyarthritis.

Key words:reactive arthritis, rheumatoid poyarthritis, oxidative stress, oxygen free radicals, catalase, glutathione peroxidase, superoxide dismutaseFULL TEXT.PDF


†††† Epidemiology: communicable diseases


Trends of leptospirosis in eastern counties of Romania during the past two decades

Angela Romaniuc, Raluca Mihaela Filimon, Anca Nistor, Mariana Virlan, Mihaela Debita, Elena Duca, Anca Dancau, Roxana Pipirigeanu, Marina Maiorov, Ecaterina Chihaia, V. Morariu

Abstract. Leptospirosis is a zooanthroponosis with major implication for the public health. The incidence of the disease rises during the last decade in eastern counties of Romania. The change that occurred in agricultural sector brought mutations in the epidemiological process. Leptospirosis registered during past years a trend to dispersion the rural area. There are involved all the active age group in close relation into occupational hazards (plumbers, animal breeders). The clinical evolution of the disease is a sever one (21%) with a fatality rate of 4.5% and the specific mortality of 0.14 o/oooo. The incriminated serotypes found were: L. icterohaemorrhagiae, wolffi and gryppotyphosa. An efficient leptospirosis control needs a better collaboration between veterinary and human medical network.

Key words: leptospirosis, epidemiology, clinic symptoms, diagnosis, prevention and controlFULL TEXT.PDF


Immunological diagnosis in vivo and acapsular anthrax vaccine: a pioneerachievement of Romanian medical science

Elie Shlyakhov, Alla V‚ţă, Efim Platkov

Abstract: this review presents many of numerous studies realized in the past century by romanian researchers who contributed directly or indirectly to progress in animal anthrax specific prevention and imunological diagnosis of the disease. It is underlined nicolae stamatinís great contribution; he obtained a new acapsulated and attenuated vaccinal strain of b. Anthracis whose mass use led to a dramatical decrease of anthrax morbidity among animals. Many studies were performed to achieve an immunological diagnosis of the disease. The review highlights the studies performed by shlyakhov et al. On laboratory diagnosis of patients which are culture negative because of previous antibacterial therapy. The intradermal testing with anthraxin extracted from acapsulated vaccinal strain of b. Anthracis by shlyakhov et al. Offers the possibility to asses the cell mediated immunity. Anthraxin-like products adapted for elisa will be able to reveal, in vitro, the cellular immunity in vaccinated animals.

Keywords: anthrax, vaccine, immunological diagnosisFULL TEXT.PDF


†††† Experimental research


The interactions of carbon black particles with reduced glutathione (GSH) and proteins in respiratory tractlining fluid

Henryk Zieliński

Abstract. In this study we examined the impact ofcarbon black particles (CBPs) type M120 on the reduced glutathione and proteins in the respiratory tract epithelial lining fluid (ELF) using a model exposure system.Model ELF solutions without (-) and with (+) chelating agents were incubated with 500 mg/mL of CBPs in 1 mL aliquots (37oC) for 0-6h under mixed conditions. At set intervals throughout the exposure, CBPs were removed by centrifugation, and samples rapidly frozen prior to reduced glutathione (GSH), proteins and protein thiols determination. It has been demonstrated that both albumin and chelating agents can protect oxidation of reduced glutathione induced by carbon black particles.

Key words: air pollutants, respiratory tract lining fluid, albumin, reduced glutathione, proteins thiols†† FULL TEXT.PDF


Evaluation of blood enzyme and non-enzyme antioxidant status, in guinea pigs with bronchial asthma and treated with a no donor

Luminiţa Jerca, Irina Popovici, Oltiţa Jerca, Florina Filip, Nastasia Gheorghiţă, Al.T.Balaban

Abstract. Attempts have made to characterize the antioxidant potential of the early phase of bronchial asthma. An experimental model trying to mimic allergic bronchial asthma was immunologically induced with ovalbumin (OA) in guinea pigs which were then treated with a NO donor (ammonium salt of N- nitrosophenyl-N-hydroxilamine) at a concentration of 0,1 mg/Kg (1/400 of DL50) for 2 weeks. The animals were killed afterwards, for assessing the presence of cellular oxidative stress and free radicals (FR). The changes in the activity of superoxide-dismutase (SOD), glutathione-peroxidase (GPx), reduced glutathione (GSH) and malon-dialdehide (MDA), were followed in the heparinized blood of guinea pigs series (5-6 animals in series): L1 = nebulized with OA; L2 = hypersensitized with OA; L3 = hypersensitized with OA and treated intraperitoneal for 2 weeks with NO donor; L4 = controls, healthy guinea pigs.

The final data have revealed: Theincreased activity of SOD at series L3 compared to series L1 (+120.79 %) and to series L2 (+69.95 %) becoming closer to the activity of the control series; the increasedactivity of GPx at series L3, compared to series L1 (+2.48 %), to series L2 (+24.77 %) and to series L4 (+8.64 %); the decreased level of GSH at series L3, compared to series L2 (-22.18 %) and to series L1 (-15.83 %), but with an increased level compared to series L4 (+ 36.85 %); the decreased concentration of MDA at series L3 compared to series L1 (-6.52 %), to series L2 (-17,64 %) and to series L4 (-9.40 %), all these proving a lower level of the lipid peroxides and damaging free radicals. The positive effect of the NO- donor, with the above specific concentration, is due to the stimulation of the synthesis of the oxidative stress biomarkers which have an important antioxidant rol.

Key words: nitric oxide (NO), superoxide-dismutase (SOD), glutathione-peroxidase (GPx), malon-dialdehide (MDA), S-nitroso-glutathione (S-NO-GSH), bronchial asthma, oxidative stress FULL TEXT.PDF


†††† History of medicine


Prophylaxis of smallpox in Romanian traditional medicine

Cristina Ionescu

Variolation, as an empirical method of smallpox prevention, was practiced since earliest times; it was first mentioned in a Chinese medical textbook dated 1014, but it is presumed it was in use throughout the Orient.

Arabic people were familiar with rashes as well as with the other infectious diseases. The famous physician Rhazes (850-932) described smallpox and differentiated it from varicella and measles in a paper nowadays considered as the first monograph in the medical literature. Smallpox was also present in our country with epidemic waves occurring from time to time. In the writings of the Romanian chroniclers no devastating epidemic of smallpox similar to those recorded in Western Europe is described. It is believed that epidemics were of low intensity, and that the disease was endemic. Old Romanian literature mentions notable people who had smallpox, such as Stefan, the son of Radu Voda, Sigismund Bartori or Lucsandra, proposed by Matei Basarab. FULL TEXT.PDF


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